A prospective study on clinical, radiological, and pathological features in early diagnosis of spinal tuberculosis

Background: Spinal tuberculosis (TB) is the most common of musculoskeletal TB. The diagnosis spinal TB difficult due to non-specific symptoms. Clinical assessment, along with radiological features and biopsy, plays an important role in early Aims Objectives: aims this study were analyze clinical, radiological, pathological for identify other conditions mimicking Materials Methods: present prospective includes 110 patients. All patients clinically radiologically examined. underwent percutaneous biopsy involved region tissue samples subjected histopathological examination (HPE) cartridge-based nucleic acid amplification test (CBNAAT) definitive Results: Out cases, male preponderance (65.5%) was seen comparison females (34.5%). Dorsal spine (53.7%) lumbar (41.3%) site involvement. One hundred confirmed as by histopathology molecular diagnosis. Histopathology alone could make 40 cases while 100 10 non-tuberculous etiology (metastatic deposits carcinoma five pyogenic spondylodiscitis three primary neoplastic lesion two one case giant cell tumor, hemangioma each). Conclusion: a deep-seated paucibacillary condition diagnose inadequate sample. Therefore, multipronged approach direct smear examination, HPE, required Culture gold standard CBNAAT highly sensitive specific that enables rapid detection tubercular bacilli should be considered first-line test.